Antonelli is the daughter of Hilton Prado and Suely Antonelli. She has a brother named Leonardo Pietro Antonelli. She has a nephew named Gabriel. She married businessman Ricardo Medina on March 8, 2000. They separated in February 2002.
In late 2001, Antonelli started dating the actor Murilo Benício. He was her co-star in O Clone. They married in 2002. Their son Pietro was born on May 24, 2005. Antonelli and Benício separated in 2005. Earlier, in 2004, during their first separation, she dated businessman Alexandre Accioly.
In 2009, Antonelli broke up with businessman Arthur Fernandes after two years.
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